osteoporosis Archives

March 31, 2021April 4, 2021

Osteoporosis in women increase risk of Parkinson’s disease

Osteoporosis in women increase risk of Parkinson's disease

According to a recent study, a women that suffered osteoporosis are more likely to develop Parkinson’s disease (PD).

Estrogen plays an important role to maintain bone strength. Therefore, women that has menopause their levels of estrogen will decrease. Hence, the rate of bone loss increases for approximately 8 to 10 years before returning to premenopausal rates. Its may lead to this disease.

“Risk of patients with early-stage PD can reduce the bone-mineral density levels and osteoporosis and PD always linked together (co-occur),” the authors said.

Taiwan’s National Health Insurance Research Database is using retrospective cohort study to test this hypothesis. In the osteoporosis group, between 2002 and 2006 the investigator enrolled 23,495 patients with osteoporosis aged 50 to 80 years and approximately 23,495 patients without osteoporosis in the comparison group.

Age, sex, comorbid conditions, and socioeconomic status is included in this study. It will be use to rate the tendency scores.

Furthermore, about 31% in the osteoporosis group is likely to develop PD than the comparison group. Thus, patients with osteoporosis is significantly having lower PD-free survival rate compare to the comparison group (p<0.001).

In a gender-based analysis, women with osteoporosis is facing higher risk of developing Parkinson’s disease than men.

According to the author, “patients with osteoporosis is at high risk of developing Parkinson’s disease, and the risk appears to be greater in women.”

However, further research need to investigate the mechanisms underlying findings.

References:

https://specialty.mims.com/topic/women-with-osteoporosis-at-greater-risk-of-developing-parkinson-s-disease?topic-grouper=news

August 24, 2020August 4, 2021

Reducing risks of osteoporosis fractures in Crohn’s disease with impact and resistance training

Crohn's Disease and Osteoporosis

Crohn’s Disease (CD) is a type of inflammatory bowel disease which causes your digestive tract to be swollen and irritated.

Amazingly, CD is also linked with osteoporosis.

This is due to the inability of the small intestines to absorb nutrients, including Vitamin D.

Thus causing Vitamin D deficiency, a vitamin that is important for the formation of bones.

This in turn may result in osteoporosis.

The link between CD and osteoporosis is also associated with inflammation, high-dose corticosteroid use, as well as a lack of exercise and physical activity.

Studies on Impact of Exercise to Increase Bone Mineral Density (BMD)

A recent study shows that combined impact and resistance training exercises help raise bone mineral density and muscle function.

Thus, benefiting patients with Crohn’s disease (CD).

CD patients have a high risk of developing osteoporosis and related fractures.

Researchers selected adults with stable CD and were assigned to undergo an exercise intervention or receive usual care alone for 6 months.

Usual care plus a combined impact and resistance training program was given to the exercise group.

Whereas patients underwent three 60-minutes sessions per week, with a gradual tapering of supervision to self-management.

Most of the patients had the quiescent disease and none of the patients smoked.

Result of The Study

216 months median time since the CD diagnosis and according to baseline BMD measurements, 12 patients had evidence of osteopenia or osteoporosis at the lumbar spine and 20 at the left hip.

The most common medications used for CD were immunosuppressants and biologics; none were on corticosteroids.

The bone mineral density (BMD) values were better in the exercise group vs the control group at 6 months.

Moreover, the difference is significant at the lumbar spine, but not at femoral neck nor at the greater trochanter.

Even though there were three exercise-related adverse events (for instance light-headedness and nausea) the intervention yielded improvements in all muscle function outcomes and fatigue severity.

The findings highlight the intervention as a suitable model of exercise for reducing the future risk of osteoporotic fractures and physical disability in this high‐risk population.

For more articles alike, click HERE!

References

https://specialty.mims.com/

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August 13, 2020July 19, 2021

Early ageing of ovary: A future health problem?

Source from MIMS.com

A large cohort study that was presented at the 2020 ESHRE Meeting suggested that early ovarian ageing may be predictive of later health problems.

Few oocytes in Assisted Reproductive Technology (Art) were harvested from young women with premature ovarian ageing and were discovered to have a much higher risk of age-related diseases such as cardiovascular diseases (CVD) and osteoporosis compared to those with undergoing normal ovarian ageing and happens to be in line with what was known so far regarding early menopause.

Mette Wulf Christensen from Aarhus University in Denmark suggested that a few oocytes that were repeatedly harvested in well stimulated ART cycles is a likely predictor of advanced menopausal age when seen in young women and may thus serve as an early marker of accelerated general ageing. There is also an association shown between early menopause with a greater risk of CVD, osteoporosis, and death. She also said that identifying women at risk of early menopause may thus allow early preventive health initiatives in terms of a healthy lifestyle.

The national cohort study that was based in Danish included >19,000 young women (≤37 years) who were undergoing their first ART treatment in a fertility clinic between the period of 1995-2014 with the number of oocytes harvested in the first and following cycles serves as a marker.

In a follow-up of 6 years span, women with early ovarian ageing for overall-disease risk has a higher risk than those with a normal oocyte field and they consisted of Alzheimer’s or Parkinson’s disease, all-cause death, cancer, cataract, Charlson Comorbidity index, CVD, early retirement benefit, osteoporosis and type 2 diabetes.

To be specific, the early ovarian ageing group was significantly more likely to develop osteoporosis, CVD, comorbidity, and have early retirement benefit than women with normal ovarian ageing.

Christhensen concluded that it is important to have a counselling towards the women who are affected with a much earlier menopause, with the introduction of a new lifestyle habit or applying the use of hormone replacement therapy (HRT) to reduce the adverse health risks.

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Tag: osteoporosis