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Bleeding and cardiovascular risks heightens after consumption of NSAIDs


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Researchers conducted a study that investigated the risk for cardiovascular and bleeding events according to groups of antithrombotic medications and subtypes of NSAIDs. The first diagnosed MI in the nationwide cohort study was retrieved from 108,232 patients that they have accessed the Health Insurance Review and Assessment Service database between 2009 and 2013.

Based on their prescribed antithrombotic medications, the patients were divided into groups  with the thromboembolic cardiovascular and clinically relevant bleeding events as the study outcomes.

Concomitant NSAID treatment significantly elevated the risk for cardiovascular events and bleeding events compared with no NSAID treatment over a mean follow-up of 2.3 years. Celecoxib and meloxicam showed the lowest risk of cardiovascular and bleeding events among NSAID subtypes.

The authors stated in their research that although NSAID treatment should be avoided after MI, celecoxib and meloxicam could be considered as alternative options in cases in which NSAID use is unavoidable.

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Lower risks of cancer, cardiovascular diseases and diabetes by having more fibres in your diet

Cr. Joanna Kosinka

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A recent study suggests that to reduce the risk of several chronic diseases and mortality, higher consumption of dietary fibres (DF), particularly soluble (SF) and insoluble fibres (IF) from fruits.

The researchers sought to examine the association of intake of DFs of different types (total DF, SF and IF) and from various sources with the risk of cardiovascular disease (CVDs), cancer, type 2 diabetes (T2D), and mortality in the large-scale NutriNet-Santé prospective cohort.

107,377 participants were included in the cohort study where the usual DF intake was estimated from validated repeated 24-h dietary records over the first 2 years following inclusion in the cohort. To assess the associations between sex-specific quintiles of DF intake and the risk of chronic diseases and mortality.

With the increased intake of total DFs, it was found that T2D risk is being significantly decreased and also correlated with a lower risk of breast cancer. It is also stated that intake from fruits led to a reduced risk of several chronic diseases. . For particularly soluble (SFs), they are correlated with a reduced risk of CVD and colorectal cancer, while IFs reduce mortality from cancer or CVDs.

The investigators stated that to involve different types and sources of fibre, further studies are needed and more emphasis should be put on dietary fibres in public health nutrition policies, as DF intake remains below the recommended levels in many countries.

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Early ageing of ovary: A future health problem?

Cr. Andre Piacquadio

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A large cohort study that was presented at the 2020 ESHRE Meeting suggested that early ovarian ageing may be predictive of later health problems.

Few oocytes in Assisted Reproductive Technology (Art) were harvested from young women with premature ovarian ageing and were discovered to have a much higher risk of age-related diseases such as cardiovascular diseases (CVD) and osteoporosis compared to those with undergoing normal ovarian ageing and happens to be in line with what was known so far regarding early menopause.

Mette Wulf Christensen from Aarhus University in Denmark suggested that a few oocytes that were repeatedly harvested in well stimulated ART cycles is a likely predictor of advanced menopausal age when seen in young women and may thus serve as an early marker of accelerated general ageing. There is also an association shown between early menopause with a greater risk of CVD, osteoporosis, and death. She also said that identifying women at risk of early menopause may thus allow early preventive health initiatives in terms of  a healthy lifestyle.

The national cohort study that was based in Danish included >19,000 young women (≤37 years) who were undergoing their first ART treatment in a fertility clinic between the period of 1995-2014 with the number of oocytes harvested in the first and following cycles serves as a marker.

In a follow-up of 6 years span, women with early ovarian ageing for overall-disease risk has a higher risk than those with a normal oocyte field and they consisted of Alzheimer’s or Parkinson’s disease, all-cause death, cancer, cataract, Charlson Comorbidity index, CVD, early retirement benefit, osteoporosis and type 2 diabetes.

To be specific, the early ovarian ageing group was significantly more likely to develop osteoporosis, CVD, comorbidity, and have early retirement benefit than women with normal ovarian ageing.

Christhensen concluded that it is important to have a counselling towards the women who are affected with a much earlier menopause, with the introduction of a new lifestyle habit or  applying the use of hormone replacement therapy (HRT) to reduce the adverse health risks.

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